PRT1/YOR361C Summary Help

PRT1 BASIC INFORMATION

Standard Name PRT1
Systematic Name YOR361C
Alias CDC63 1 , DNA26 2
Feature Type ORF, Verified
Description eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes (3, 4, 5, 6)
Name Description PRoTein synthesis
GO Annotations All PRT1 GO evidence and references
    View Computational GO annotations for PRT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All PRT1 Phenotype details and references
Classical genetics
conditional
Large-scale survey
null
repressible
Interactions PRT1 All interactions details and references
197 total interaction(s) for 67 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 97
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 49
  • Co-fractionation: 7
  • Co-purification: 8
  • Reconstituted Complex: 15
  • Two-hybrid: 7
Genetic Interactions
  • Dosage Rescue: 3
  • Phenotypic Enhancement: 3
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 6
Sequence Information
ChrXV:1017650 to 1015359 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 221 cM
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2292 1017650..1015359 2006-01-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005888

PRT1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for PRT1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PRT1]

1) Bedard DP, et al.  (1981) New mutations in the yeast Saccharomyces cerevisiae affecting completion of Start. Curr Genet 4:205-214
2) Dumas LB, et al.  (1982) New temperature-sensitive mutants of Saccharomyces cerevisiae affecting DNA replication. Mol Gen Genet 187(1):42-6
3) Phan L, et al.  (1998) Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5. Mol Cell Biol 18(8):4935-46
4) Naranda T, et al.  (1994) Purified yeast translational initiation factor eIF-3 is an RNA-binding protein complex that contains the PRT1 protein. J Biol Chem 269(51):32286-92
5) Keierleber C, et al.  (1986) Isolation and characterization of PRT1, a gene required for the initiation of protein biosynthesis in Saccharomyces cerevisiae. Mol Cell Biol 6(12):4419-24
6) Phan L, et al.  (2001) A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNA(i)Met. EMBO J 20(11):2954-65