Standard Name	PRT1
Systematic Name	YOR361C
Alias	CDC63 1 , DNA26 2
Feature Type	ORF, Verified
Description	eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes (3, 4, 5, 6)
Name Description	PRoTein synthesis

Chromosomal Location	ChrXV:1017652 to 1015361 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 221 cM

	View Computational GO annotations for PRT1
Molecular Function
Manually curated	translation initiation factor activity (IDA, IPI, ISS)
Biological Process
Manually curated	translational initiation (IDA, IMP)
Cellular Component
Manually curated	cytoplasm (IPI) cytoplasmic stress granule (IDA) eukaryotic translation initiation factor 3 complex (IDA, IPI) multi-eIF complex (IDA)

Classical genetics
conditional	cell cycle passage through START: arrested cell cycle progression in G1 phase: arrested heat sensitivity: increased
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal
null	inviable
reduction of function	competitive fitness: normal
repressible	cell cycle progression in G1 phase: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	278 total interaction(s) for 112 unique genes/features.
Physical Interactions	Affinity Capture-MS: 126 Affinity Capture-RNA: 2 Affinity Capture-Western: 68 Biochemical Activity: 1 Co-crystal Structure: 2 Co-fractionation: 7 Co-purification: 8 PCA: 1 Reconstituted Complex: 19 Two-hybrid: 7
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 17 Phenotypic Enhancement: 3 Phenotypic Suppression: 2 Positive Genetic: 3 Synthetic Growth Defect: 5 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:1017652 to 1015361 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 221 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2292 1017652..1015361 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005888