PRS4/YBL068W Summary Help

PRS4 BASIC INFORMATION

Standard Name PRS4 1
Systematic Name YBL068W
Feature Type ORF, Verified
Description 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes (1, 2, 3)
Name Description PhosphoRibosylpyrophosphate Synthetase 4
GO Annotations All PRS4 GO evidence and references
    View Computational GO annotations for PRS4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Pathways
Mutant Phenotype All PRS4 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions PRS4 All interactions details and references
16 total interaction(s) for 13 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • PCA: 2
  • Two-hybrid: 3
Genetic Interactions
  • Phenotypic Enhancement: 4
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 2
Sequence Information
ChrII:92412 to 93395 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-01-29 | Sequence: 2003-09-22
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..984 92412..93395 2004-01-29 2003-09-22
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000164

PRS4 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for PRS4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PRS4]

1) Carter AT, et al.  (1997) PRS1 is a key member of the gene family encoding phosphoribosylpyrophosphate synthetase in Saccharomyces cerevisiae. Mol Gen Genet 254(2):148-56
2) Hernando Y, et al.  (1999) Genetic analysis and enzyme activity suggest the existence of more than one minimal functional unit capable of synthesizing phosphoribosyl pyrophosphate in Saccharomyces cerevisiae. J Biol Chem 274(18):12480-7
3) Hernando Y, et al.  (1998) PRS5, the fifth member of the phosphoribosyl pyrophosphate synthetase gene family in Saccharomyces cerevisiae, is essential for cell viability in the absence of either PRS1 or PRS3. J Bacteriol 180(23):6404-7
4) Carter AT, et al.  (1994) Phosphoribosylpyrophosphate synthetase (PRS): a new gene family in Saccharomyces cerevisiae. Yeast 10(8):1031-44