PRS2/YER099C Summary Help

PRS2 BASIC INFORMATION

Standard Name PRS2 1
Systematic Name YER099C
Feature Type ORF, Verified
Description 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes (1, 2, 3)
Name Description PhosphoRibosylpyrophosphate Synthetase 4
GO Annotations All PRS2 GO evidence and references
    View Computational GO annotations for PRS2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Pathways
Mutant Phenotype All PRS2 Phenotype details and references
Classical genetics
null
Interactions PRS2 All interactions details and references
19 total interaction(s) for 9 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • PCA: 3
  • Two-hybrid: 11
Genetic Interactions
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1
Sequence Information
ChrV:359057 to 358101 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..957 359057..358101 1996-07-31 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000901

PRS2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for PRS2

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
SCL1Nomenclature conflictThe PRS2 name has been used to describe both SCL1/YGL011C, a proteosome subunit, and PRS2/YER099C, a ribose-phosphate pyrophosphokinase.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PRS2]

1) Carter AT, et al.  (1997) PRS1 is a key member of the gene family encoding phosphoribosylpyrophosphate synthetase in Saccharomyces cerevisiae. Mol Gen Genet 254(2):148-56
2) Hernando Y, et al.  (1999) Genetic analysis and enzyme activity suggest the existence of more than one minimal functional unit capable of synthesizing phosphoribosyl pyrophosphate in Saccharomyces cerevisiae. J Biol Chem 274(18):12480-7
3) Hernando Y, et al.  (1998) PRS5, the fifth member of the phosphoribosyl pyrophosphate synthetase gene family in Saccharomyces cerevisiae, is essential for cell viability in the absence of either PRS1 or PRS3. J Bacteriol 180(23):6404-7
4) Carter AT, et al.  (1994) Phosphoribosylpyrophosphate synthetase (PRS): a new gene family in Saccharomyces cerevisiae. Yeast 10(8):1031-44