Standard Name	PRS1 1
Systematic Name	YKL181W
Alias	PRP1
Feature Type	ORF, Verified
Description	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes (1, 2, 3)
Name Description	PhosphoRibosylpyrophosphate Synthetase 4

Chromosomal Location	ChrXI:107316 to 108599 | ORF Map | GBrowse

	View Computational GO annotations for PRS1
Molecular Function
Manually curated	contributes_to ribose phosphate diphosphokinase activity (IGI)
Biological Process
Manually curated	5-phosphoribose 1-diphosphate biosynthetic process (IGI, IMP) fungal-type cell wall organization (IPI)
Cellular Component
Manually curated	cytoplasm (IDA)
High-throughput	cytoplasm (IDA)

Pathways	superpathway of histidine, purine, and pyrimidine biosynthesis

Classical genetics
null	purine ribonucleotide accumulation: decreased pyrimidine ribonucleotide accumulation: decreased heat sensitivity: increased resistance to lithium chloride: decreased resistance to valproic acid: decreased resistance to Calcofluor White: increased resistance to caffeine: decreased viable
Large-scale survey
null	haploinsufficient heat sensitivity: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	49 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 2 Biochemical Activity: 6 PCA: 7 Reconstituted Complex: 11 Two-hybrid: 7
Genetic Interactions	Synthetic Growth Defect: 1 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:107316 to 108599 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1284 107316..108599 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001664