PRP5/YBR237W Summary Help

PRP5 BASIC INFORMATION

Standard Name PRP5
Systematic Name YBR237W
Alias RNA5
Feature Type ORF, Verified
Description RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (1, 2, 3)
Name Description Pre-mRNA Processing 4
GO Annotations All PRP5 GO evidence and references
    View Computational GO annotations for PRP5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All PRP5 Phenotype details and references
Classical genetics
conditional
Large-scale survey
null
overexpression
Interactions PRP5 All interactions details and references
17 total interaction(s) for 14 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
  • PCA: 1
  • Protein-RNA: 1
  • Two-hybrid: 2
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 2
  • Synthetic Rescue: 2
Sequence Information
ChrII:691964 to 694513 | ORF Map | GBrowse
Gbrowse
Genetic position: 138 cM
Last Update Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2550 691964..694513 2004-07-16 1997-01-28
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000441

PRP5 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Phenotype Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for PRP5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PRP5]

1) de la Cruz J, et al.  (1999) Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. Trends Biochem Sci 24(5):192-8
2) Abu Dayyeh BK, et al.  (2002) Probing interactions between the U2 small nuclear ribonucleoprotein and the DEAD-box protein, Prp5. J Biol Chem 277(23):20221-33
3) Xu YZ, et al.  (2004) Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA. EMBO J 23(2):376-85
4) Vijayraghavan U, et al.  (1989) Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae. Genes Dev 3(8):1206-16