Standard Name	PRP39
Systematic Name	YML046W
Feature Type	ORF, Verified
Description	U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats (1, 2, 3)
Name Description	Pre-mRNA Processing

Chromosomal Location	ChrXIII:181474 to 183363 | ORF Map | GBrowse

	View Computational GO annotations for PRP39
Molecular Function
Manually curated	contributes_to pre-mRNA 5'-splice site binding (IGI)
Biological Process
Manually curated	mRNA 5'-splice site recognition (IGI)
Cellular Component
Manually curated	commitment complex (IGI) U1 snRNP (IDA) U2-type prespliceosome (IDA)

Large-scale survey
null	haploproficient inviable
reduction of function	competitive fitness: decreased resistance to sirolimus: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	89 total interaction(s) for 44 unique genes/features.
Physical Interactions	Affinity Capture-MS: 76 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Co-purification: 1 Two-hybrid: 4
Genetic Interactions	Dosage Lethality: 2 Negative Genetic: 1 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:181474 to 183363 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1890 181474..183363 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004509