PRP39/YML046W Summary

PRP39 BASIC INFORMATION

Standard Name	PRP39
Systematic Name	YML046W
Feature Type	ORF, Verified
Description	U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats (1, 2, 3)
Name Description	Pre-mRNA Processing

GO Annotations	All PRP39 GO evidence and references
	View Computational GO annotations for PRP39
Molecular Function
Manually curated	contributes_to pre-mRNA 5'-splice site binding (IGI)
Biological Process
Manually curated	nuclear mRNA 5'-splice site recognition (IGI)
Cellular Component
Manually curated	commitment complex (IGI) U1 snRNP (IDA) U2-type prespliceosome (IDA)

Mutant Phenotype	All PRP39 Phenotype details and references
Large-scale survey
null	inviable

Interactions	PRP39 All interactions details and references
	72 total interaction(s) for 34 unique genes/features.
Physical Interactions	Affinity Capture-MS: 63 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Co-purification: 1 Two-hybrid: 4
Genetic Interactions	Dosage Lethality: 2

Sequence Information

ChrXIII:181474 to 183363 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1890	181474..183363	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004509

PRP39 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PRP39

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PRP39]

1)	Lockhart SR and Rymond BC (1994) Commitment of yeast pre-mRNA to the splicing pathway requires a novel U1 small nuclear ribonucleoprotein polypeptide, Prp39p. Mol Cell Biol 14(6):3623-33
2)	Gottschalk A, et al. (1998) A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins. RNA 4(4):374-93
3)	Zhang D and Rosbash M (1999) Identification of eight proteins that cross-link to pre-mRNA in the yeast commitment complex. Genes Dev 13(5):581-92

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