PRP16/YKR086W Summary Help

PRP16 BASIC INFORMATION

Standard Name PRP16 1
Systematic Name YKR086W
Alias RNA16 2 , PRP23 3 , 4
Feature Type ORF, Verified
Description RNA helicase in the DEAH-box family involved in the second catalytic step of splicing, exhibits ATP-dependent RNA unwinding activity (5, 6)
Name Description Pre-mRNA Processing 4
GO Annotations All PRP16 GO evidence and references
    View Computational GO annotations for PRP16
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All PRP16 Phenotype details and references
Classical genetics
null
unspecified
Large-scale survey
null
Interactions PRP16 All interactions details and references
31 total interaction(s) for 15 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-Western: 3
  • Co-fractionation: 1
  • Two-hybrid: 3
Genetic Interactions
  • Dosage Rescue: 2
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 17
  • Synthetic Rescue: 2
Sequence Information
ChrXI:599499 to 602714 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2005-12-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3216 599499..602714 2005-12-15 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001794

PRP16 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for PRP16

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PRP16]

1) Burgess S, et al.  (1990) A putative ATP binding protein influences the fidelity of branchpoint recognition in yeast splicing. Cell 60(5):705-17
2) Couto JR, et al.  (1987) A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation. Genes Dev 1(5):445-55
3) Schwer B and Guthrie C  (1991) PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome. Nature 349(6309):494-9
4) Vijayraghavan U, et al.  (1989) Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae. Genes Dev 3(8):1206-16
5) Wang Y, et al.  (1998) The DEAH-box splicing factor Prp16 unwinds RNA duplexes in vitro. Curr Biol 8(8):441-51
6) Umen JG and Guthrie C  (1995) The second catalytic step of pre-mRNA splicing. RNA 1(9):869-85