PRM8/YGL053W Summary Help

Standard Name PRM8 1
Systematic Name YGL053W
Feature Type ORF, Verified
Description Pheromone-regulated protein; contains with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family; PRM8 has a paralog, PRM9, that arose from a segmental duplication (1, 2, 3, 4, 5)
Name Description Pheromone-Regulated Membrane protein 1
Chromosomal Location
ChrVII:402589 to 403302 | ORF Map | GBrowse
Gene Ontology Annotations All PRM8 GO evidence and references
  View Computational GO annotations for PRM8
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Large-scale survey
26 total interaction(s) for 26 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 1
  • Co-purification: 1
  • PCA: 4
  • Two-hybrid: 9

Genetic Interactions
  • Negative Genetic: 8
  • Positive Genetic: 1
  • Synthetic Growth Defect: 2

Expression Summary
Length (a.a.) 237
Molecular Weight (Da) 27,250
Isoelectric Point (pI) 4.86
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:402589 to 403302 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..714 402589..403302 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003021
References cited on this page View Complete Literature Guide for PRM8
1) Heiman MG and Walter P  (2000) Prm1p, a pheromone-regulated multispanning membrane protein, facilitates plasma membrane fusion during yeast mating. J Cell Biol 151(3):719-30
2) Feuermann M, et al.  (1997) The characterization of two new clusters of duplicated genes suggests a 'Lego' organization of the yeast Saccharomyces cerevisiae chromosomes. Yeast 13(9):861-9
3) Sandmann T, et al.  (2003) Suppression of coatomer mutants by a new protein family with COPI and COPII binding motifs in Saccharomyces cerevisiae. Mol Biol Cell 14(8):3097-113
4) Poirey R, et al.  (2002) Functional analysis of the Saccharomyces cerevisiae DUP240 multigene family reveals membrane-associated proteins that are not essential for cell viability. Microbiology 148(Pt 7):2111-23
5) Katju V, et al.  (2009) Variation in gene duplicates with low synonymous divergence in Saccharomyces cerevisiae relative to Caenorhabditis elegans. Genome Biol 10(7):R75