PRM3/YPL192C Summary Help

Standard Name PRM3 1
Systematic Name YPL192C
Feature Type ORF, Verified
Description Protein required for nuclear envelope fusion during karyogamy; pheromone-regulated; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body (1, 2, 3, 4)
Name Description Pheromone-Regulated Membrane protein 1
Chromosomal Location
ChrXVI:183056 to 182655 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PRM3 GO evidence and references
Molecular Function
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
conditional
null
overexpression
reduction of function
Large-scale survey
null
Resources
27 total interaction(s) for 21 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-Western: 1
  • Co-localization: 1
  • Two-hybrid: 4

Genetic Interactions
  • Negative Genetic: 11
  • Positive Genetic: 2
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 133
Molecular Weight (Da) 14,428
Isoelectric Point (pI) 11.11
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:183056 to 182655 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..402 183056..182655 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006113
References cited on this page View Complete Literature Guide for PRM3
1) Heiman MG and Walter P  (2000) Prm1p, a pheromone-regulated multispanning membrane protein, facilitates plasma membrane fusion during yeast mating. J Cell Biol 151(3):719-30
2) White JM and Rose MD  (2001) Yeast mating: getting close to membrane merger. Curr Biol 11(1):R16-20
3) Beilharz T, et al.  (2003) Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae. J Biol Chem 278(10):8219-23
4) Shen S, et al.  (2009) Prm3p is a pheromone-induced peripheral nuclear envelope protein required for yeast nuclear fusion. Mol Biol Cell 20(9):2438-50