Standard Name	PPZ1
Systematic Name	YML016C
Feature Type	ORF, Verified
Description	Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance; PPZ1 has a paralog, PPZ2, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Protein Phosphatase Z 5

Chromosomal Location	ChrXIII:241536 to 239458 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PPZ1
Molecular Function
Manually curated	protein serine/threonine phosphatase activity (IDA)
Biological Process
Manually curated	cellular protein localization (IMP) cellular sodium ion homeostasis (IGI, IMP) protein dephosphorylation (IMP)
Cellular Component
Manually curated	extrinsic to plasma membrane (IDA) nucleus (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Regulatory modules	predicted: cellcycle (353)

Classical genetics
null	chromosome/plasmid maintenance: abnormal ionic stress resistance: increased resistance to caffeine: decreased
overexpression	nuclear morphology: abnormal
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to sirolimus: decreased resistance to caffeine: decreased resistance to mycophenolic acid: increased resistance to fluconazole: increased resistance to fenpropimorph: increased resistance to tetramethylammonium: increased resistance to spermine: increased resistance to hygromycin B: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to sodium arsenite: decreased resistance to bleomycin: decreased resistance to camptothecin: decreased resistance to hydroxyurea: decreased resistance to sodium selenide: decreased resistance to arsenite(3-): decreased transposable element transposition: increased vacuolar morphology: abnormal viable
overexpression	cell cycle progression: abnormal filamentous growth: increased vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	258 total interaction(s) for 176 unique genes/features.
Physical Interactions	Affinity Capture-MS: 27 Affinity Capture-RNA: 3 Affinity Capture-Western: 4 Biochemical Activity: 1 PCA: 39 Reconstituted Complex: 4 Two-hybrid: 12
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 8 Negative Genetic: 80 Phenotypic Enhancement: 6 Phenotypic Suppression: 2 Positive Genetic: 28 Synthetic Growth Defect: 20 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 10 Synthetic Rescue: 12
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:241536 to 239458 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2079 241536..239458 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004478