PPZ1/YML016C Summary Help

PPZ1 BASIC INFORMATION

Standard Name PPZ1
Systematic Name YML016C
Feature Type ORF, Verified
Description Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance (1, 2, 3)
Name Description Protein Phosphatase Z 4
GO Annotations All PPZ1 GO evidence and references
    View Computational GO annotations for PPZ1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulatory Role
Regulatory modules predicted: cellcycle ( 353 )
Mutant Phenotype All PPZ1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Interactions PPZ1 All interactions details and references
146 total interaction(s) for 107 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 15
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 4
  • Biochemical Activity: 1
  • PCA: 33
  • Reconstituted Complex: 3
  • Two-hybrid: 11
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 4
  • Phenotypic Enhancement: 25
  • Phenotypic Suppression: 17
  • Synthetic Growth Defect: 16
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 9
  • Synthetic Rescue: 4
Sequence Information
ChrXIII:241536 to 239458 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2079 241536..239458 1996-07-31 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004478

PPZ1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for PPZ1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PPZ1]

1) Posas F, et al.  (1995) Biochemical characterization of recombinant yeast PPZ1, a protein phosphatase involved in salt tolerance. FEBS Lett 368(1):39-44
2) Hughes V, et al.  (1993) Both isoforms of protein phosphatase Z are essential for the maintenance of cell size and integrity in Saccharomyces cerevisiae in response to osmotic stress. Eur J Biochem 216(1):269-79
3) Yenush L, et al.  (2002) The Ppz protein phosphatases are key regulators of K+ and pH homeostasis: implications for salt tolerance, cell wall integrity and cell cycle progression. EMBO J 21(5):920-9
4) Da Cruz e Silva EF, et al.  (1991) Protein phosphatase 2Bw and protein phosphatase Z are Saccharomyces cerevisiae enzymes. Biochim Biophys Acta 1089(2):269-72