PPR1/YLR014C Summary Help

Standard Name PPR1
Systematic Name YLR014C
Feature Type ORF, Verified
Description Zinc finger transcription factor; contains a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p (1, 2, 3, 4)
Name Description Pyrimidine Pathway Regulation
Chromosomal Location
ChrXII:174982 to 172268 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 8 cM
Gene Ontology Annotations All PPR1 GO evidence and references
  View Computational GO annotations for PPR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 21 genes
Regulators 2 genes
Resources
Large-scale survey
null
Resources
37 total interaction(s) for 36 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Co-crystal Structure: 1

Genetic Interactions
  • Negative Genetic: 20
  • Positive Genetic: 3
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 904
Molecular Weight (Da) 102,723
Isoelectric Point (pI) 7.31
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:174982 to 172268 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: 8 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2715 174982..172268 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004004
References cited on this page View Complete Literature Guide for PPR1
1) Todd RB and Andrianopoulos A  (1997) Evolution of a fungal regulatory gene family: the Zn(II)2Cys6 binuclear cluster DNA binding motif. Fungal Genet Biol 21(3):388-405
2) Flynn PJ and Reece RJ  (1999) Activation of transcription by metabolic intermediates of the pyrimidine biosynthetic pathway. Mol Cell Biol 19(1):882-8
3) Liljelund P, et al.  (1984) Yeast regulatory gene PPR1. II. Chromosomal localization, meiotic map, suppressibility, dominance/recessivity and dosage effect. J Mol Biol 180(2):251-65
4) Patzold AJ and Lehming N  (2001) Why Ppr1p is a weak activator of transcription. FEBS Lett 494(1-2):64-8