PPQ1/YPL179W Summary Help

Standard Name PPQ1 1
Systematic Name YPL179W
Alias SAL6
Feature Type ORF, Verified
Description Protein phosphatase that regulates the mating response; negatively regulates the MAP kinase signaling cascade during mating; member of the serine/threonine phosphatase PP1 family (1, 2, 3, 4)
Name Description Protein Phosphatase Q 1
Chromosomal Location
ChrXVI:208157 to 209806 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PPQ1 GO evidence and references
  View Computational GO annotations for PPQ1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
unspecified
Resources
49 total interaction(s) for 47 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 3
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 23
  • Positive Genetic: 15
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 549
Molecular Weight (Da) 61,420
Isoelectric Point (pI) 10.08
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:208157 to 209806 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1650 208157..209806 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006100
References cited on this page View Complete Literature Guide for PPQ1
1) Chen MX, et al.  (1993) PPQ, a novel protein phosphatase containing a Ser + Asn-rich amino-terminal domain, is involved in the regulation of protein synthesis. Eur J Biochem 218(2):689-99
2) Stark MJ  (1996) Yeast protein serine/threonine phosphatases: multiple roles and diverse regulation. Yeast 12(16):1647-75
3) Vincent A, et al.  (1994) The yeast translational allosuppressor, SAL6: a new member of the PP1-like phosphatase family with a long serine-rich N-terminal extension. Genetics 138(3):597-608
4) Shim E and Park SH  (2014) Identification of a novel Ser/Thr protein phosphatase Ppq1 as a negative regulator of mating MAP kinase pathway in Saccharomyces cerevisiae. Biochem Biophys Res Commun 443(1):252-8