Standard Name	PPM1 1
Systematic Name	YDR435C
Feature Type	ORF, Verified
Description	Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits (1, 2, 3)
Name Description	Protein Phosphatase Methyltransferase 1

Chromosomal Location	ChrIV:1333969 to 1332983 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PPM1
Molecular Function
Manually curated	protein C-terminal leucine carboxyl O-methyltransferase activity (IMP)
Biological Process
Manually curated	C-terminal protein methylation (IMP) cellular protein complex assembly (IMP)
Cellular Component
Manually curated	cellular_component unknown (ND)

Classical genetics
null	heat sensitivity: increased resistance to sirolimus: increased resistance to benomyl: decreased resistance to nocodazole: decreased vegetative growth: decreased vegetative growth: decreased rate viability: decreased viable
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased metal resistance: increased resistance to sirolimus: increased resistance to wortmannin: increased resistance to quinine: increased resistance to ethanol: decreased resistance to neothyonidioside: decreased resistance to sodium selenide: decreased resistance to calcium dichloride: decreased viable
overexpression	filamentous growth: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	132 total interaction(s) for 92 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1
Genetic Interactions	Negative Genetic: 109 Positive Genetic: 8 Synthetic Growth Defect: 12 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1333969 to 1332983 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..987 1333969..1332983 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002843