PPM1/YDR435C Summary Help

Standard Name PPM1 1
Systematic Name YDR435C
Feature Type ORF, Verified
Description Carboxyl methyltransferase; methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits; required for methionine to inhibit autophagy and promote growth (1, 2, 3, 4)
Name Description Protein Phosphatase Methyltransferase 1
Chromosomal Location
ChrIV:1333969 to 1332983 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PPM1 GO evidence and references
  View Computational GO annotations for PPM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 63 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
133 total interaction(s) for 92 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Negative Genetic: 110
  • Positive Genetic: 8
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 328
Molecular Weight (Da) 37,694
Isoelectric Point (pI) 7.34
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1333969 to 1332983 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..987 1333969..1332983 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002843
References cited on this page View Complete Literature Guide for PPM1
1) Wu J, et al.  (2000) Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo. EMBO J 19(21):5672-81
2) Wei H, et al.  (2001) Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p. J Biol Chem 276(2):1570-7
3) Kalhor HR, et al.  (2001) Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast. Arch Biochem Biophys 395(2):239-45
4) Sutter BM, et al.  (2013) Methionine Inhibits Autophagy and Promotes Growth by Inducing the SAM-Responsive Methylation of PP2A. Cell 154(2):403-15