PPH3/YDR075W Summary Help

PPH3 BASIC INFORMATION

Standard Name PPH3 1
Systematic Name YDR075W
Feature Type ORF, Verified
Description Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p (2, 3, 4)
Name Description Protein PHosphatase
GO Annotations All PPH3 GO evidence and references
    View Computational GO annotations for PPH3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulatory Role
Regulatory modules predicted: stressResponse ( 589 , 559 )
Mutant Phenotype All PPH3 Phenotype details and references
Classical genetics
null
Large-scale survey
null
overexpression
Interactions PPH3 All interactions details and references
160 total interaction(s) for 98 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 45
  • Affinity Capture-Western: 5
  • Biochemical Activity: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 4
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 58
  • Phenotypic Suppression: 22
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 16
Sequence Information
ChrIV:597154 to 598080 | ORF Map | GBrowse
Gbrowse
Genetic position: 53 cM
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..927 597154..598080 2008-06-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002482

PPH3 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for PPH3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PPH3]

1) Ronne, H.  (1993) Personal Communication, Mortimer Map Edition 12
2) Bertram PG, et al.  (2000) Tripartite regulation of Gln3p by TOR, Ure2p, and phosphatases. J Biol Chem 275(46):35727-33
3) Hoffmann R, et al.  (1994) The Saccharomyces cerevisiae gene PPH3 encodes a protein phosphatase with properties different from PPX, PP1 and PP2A. Yeast 10(5):567-78
4) Hastie CJ, et al.  (2006) The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatin. FEBS J 273(14):3322-34