PPH22/YDL188C Summary

PPH22 BASIC INFORMATION

Standard Name	PPH22 1
Systematic Name	YDL188C
Alias	PPH2
Feature Type	ORF, Verified
Description	Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis (1, 2, 3, 4)
Name Description	Protein PHosphatase 1

GO Annotations	All PPH22 GO evidence and references
	View Computational GO annotations for PPH22
Molecular Function
Manually curated	protein serine/threonine phosphatase activity (IDA)
Biological Process
Manually curated	actin filament organization (TAS) budding cell bud growth (TAS) G1/S transition of mitotic cell cycle (IGI) mitotic cell cycle spindle assembly checkpoint (IPI) protein amino acid dephosphorylation (IDA) regulation of translation (IPI)
Cellular Component
Manually curated	condensed nuclear chromosome, centromeric region (IDA)

Mutant Phenotype	All PPH22 Phenotype details and references
Classical genetics
null	prion formation: increased viability: increased
overexpression	budding index: abnormal cell cycle progression in G1 phase: abnormal cell size: increased cellular morphology: abnormal
Large-scale survey
null	viable
overexpression	vegetative growth: decreased

Interactions	PPH22 All interactions details and references
	109 total interaction(s) for 62 unique genes/features.
Physical Interactions	Affinity Capture-MS: 59 Affinity Capture-RNA: 1 Affinity Capture-Western: 11 Reconstituted Complex: 2 Two-hybrid: 4
Genetic Interactions	Dosage Lethality: 3 Dosage Rescue: 5 Phenotypic Enhancement: 8 Phenotypic Suppression: 4 Synthetic Growth Defect: 4 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 4 Synthetic Rescue: 3

Sequence Information

ChrIV:124999 to 123866 | |

Note: this feature is encoded on the Crick strand.

Genetic position: -102 cM

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1134	124999..123866	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002347

PPH22 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PPH22

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PPH22]

1)	Sneddon AA, et al. (1990) Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes. EMBO J 9(13):4339-46
2)	Stark MJ (1996) Yeast protein serine/threonine phosphatases: multiple roles and diverse regulation. Yeast 12(16):1647-75
3)	Wei H, et al. (2001) Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p. J Biol Chem 276(2):1570-7
4)	Zabrocki P, et al. (2002) Protein phosphatase 2A on track for nutrient-induced signalling in yeast. Mol Microbiol 43(4):835-42

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.