PPA2/YMR267W Summary Help

Standard Name PPA2 1
Systematic Name YMR267W
Alias IPP2
Feature Type ORF, Verified
Description Mitochondrial inorganic pyrophosphatase; required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate (2, 3, 4)
Name Description PyroPhosphatAse 2
Chromosomal Location
ChrXIII:801772 to 802704 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PPA2 GO evidence and references
  View Computational GO annotations for PPA2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Classical genetics
null
Large-scale survey
null
unspecified
Resources
393 total interaction(s) for 347 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Two-hybrid: 5

Genetic Interactions
  • Negative Genetic: 196
  • Phenotypic Enhancement: 1
  • Positive Genetic: 179
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 310
Molecular Weight (Da) 35,572
Isoelectric Point (pI) 7.53
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:801772 to 802704 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..933 801772..802704 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004880
References cited on this page View Complete Literature Guide for PPA2
1) Landin, M.  (1992) Personal Communication, Mortimer Map Edition 11
2) Lundin M, et al.  (1991) Yeast PPA2 gene encodes a mitochondrial inorganic pyrophosphatase that is essential for mitochondrial function. J Biol Chem 266(19):12168-72
3) Lundin M, et al.  (1992) Characterization of a mitochondrial inorganic pyrophosphatase in Saccharomyces cerevisiae. Biochim Biophys Acta 1098(2):217-23
4) Pereira-da-Silva L, et al.  (1993) Inorganic pyrophosphate gives a membrane potential in yeast mitochondria, as measured with the permeant cation tetraphenylphosphonium. Arch Biochem Biophys 304(2):310-3