PNT1/YOR266W Summary Help

Standard Name PNT1 1
Systematic Name YOR266W
Feature Type ORF, Verified
Description Mitochondrial integral inner membrane protein; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine (1, 2, 3)
Name Description PeNTamidine resistance 1
Chromosomal Location
ChrXV:821023 to 822294 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PNT1 GO evidence and references
  View Computational GO annotations for PNT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Classical genetics
null
overexpression
Large-scale survey
null
Resources
90 total interaction(s) for 67 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • PCA: 1

Genetic Interactions
  • Negative Genetic: 72
  • Positive Genetic: 3
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 6
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 423
Molecular Weight (Da) 48,934
Isoelectric Point (pI) 10.29
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:821023 to 822294 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1272 821023..822294 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005792
References cited on this page View Complete Literature Guide for PNT1
1) Ludewig G and Staben C  (1994) Characterization of the PNT1 pentamidine resistance gene of Saccharomyces cerevisiae. Antimicrob Agents Chemother 38(12):2850-6
2) He S and Fox TD  (1999) Mutations affecting a yeast mitochondrial inner membrane protein, pnt1p, block export of a mitochondrially synthesized fusion protein from the matrix. Mol Cell Biol 19(10):6598-607
3) Saracco SA and Fox TD  (2002) Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane. Mol Biol Cell 13(4):1122-31