PMP1/YCR024C-A Summary Help

Standard Name PMP1 1
Systematic Name YCR024C-A
Feature Type ORF, Verified
Description Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication (2, 3, 4)
Name Description Plasma Membrane Proteolipid 1
Chromosomal Location
ChrIII:163067 to 162945 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All PMP1 GO evidence and references
  View Computational GO annotations for PMP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Large-scale survey
57 total interaction(s) for 53 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 5
  • PCA: 13
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 2
  • Negative Genetic: 11
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 6
  • Positive Genetic: 9
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1

Expression Summary
Length (a.a.) 40
Molecular Weight (Da) 4,501
Isoelectric Point (pI) 12.09
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIII:163067 to 162945 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..123 163067..162945 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000619
References cited on this page View Complete Literature Guide for PMP1
1) Navarre C, et al.  (1992) Purification and complete sequence of a small proteolipid associated with the plasma membrane H(+)-ATPase of Saccharomyces cerevisiae. J Biol Chem 267(9):6425-8
2) Mousson F, et al.  (2002) Deciphering the role of individual acyl chains in the interaction network between phosphatidylserines and a single-spanning membrane protein. Biochemistry 41(46):13611-6
3) Coic YM, et al.  (2005) Single-spanning membrane protein insertion in membrane mimetic systems: role and localization of aromatic residues. Eur Biophys J 35(1):27-39
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61