PLB3/YOL011W Summary Help

Standard Name PLB3 1
Systematic Name YOL011W
Feature Type ORF, Verified
Description Phospholipase B (lysophospholipase) involved in lipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; PLB3 has a paralog, PLB1, that arose from the whole genome duplication (1, 2, 3)
Name Description PhosphoLipase B 1
Chromosomal Location
ChrXV:305349 to 307409 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PLB3 GO evidence and references
  View Computational GO annotations for PLB3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 8 genes
Resources
Large-scale survey
null
overexpression
Resources
62 total interaction(s) for 48 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 53
  • Phenotypic Enhancement: 1
  • Positive Genetic: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 686
Molecular Weight (Da) 75,076
Isoelectric Point (pI) 4.7
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:305349 to 307409 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2061 305349..307409 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005371
References cited on this page View Complete Literature Guide for PLB3
1) Merkel O, et al.  (1999) Characterization and function in vivo of two novel phospholipases B/lysophospholipases from Saccharomyces cerevisiae. J Biol Chem 274(40):28121-7
2) Merkel O, et al.  (2005) Regulation of activity in vitro and in vivo of three phospholipases B from Saccharomyces cerevisiae. Biochem J 387(Pt 2):489-96
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61