Standard Name	PKH3
Systematic Name	YDR466W
Feature Type	ORF, Verified
Description	Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant (1)
Name Description	Pkb-activating Kinase Homolog

Chromosomal Location	ChrIV:1395121 to 1397817 | ORF Map | GBrowse

	View Computational GO annotations for PKH3
Molecular Function
Manually curated	protein kinase activity (ISS)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	MAPK cascade involved in cell wall biogenesis (IGI)
High-throughput	protein phosphorylation (IDA)
Cellular Component
Manually curated	cellular_component unknown (ND)

Large-scale survey
null	competitive fitness: decreased competitive fitness: increased resistance to quinine: decreased resistance to tunicamycin: increased resistance to camptothecin: decreased resistance to hydroxyurea: decreased resistance to mycophenolic acid: increased resistance to cycloheximide: decreased resistance to bleomycin: increased stress resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	77 total interaction(s) for 72 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 6 Reconstituted Complex: 20 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 21 Positive Genetic: 12 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1395121 to 1397817 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2697 1395121..1397817 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002874