PIP2/YOR363C Summary Help

Standard Name PIP2 1
Systematic Name YOR363C
Alias OAF2 2
Feature Type ORF, Verified
Description Oleate-specific transcriptional activator of peroxisome proliferation; autoregulatory; contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication (1, 3, 4)
Name Description Peroxisome Induction Pathway 1
Chromosomal Location
ChrXV:1023212 to 1020222 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PIP2 GO evidence and references
  View Computational GO annotations for PIP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Targets 46 genes
Regulators 1 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
Resources
26 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 1
  • Co-localization: 3
  • Reconstituted Complex: 2

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 7
  • Phenotypic Suppression: 1
  • Positive Genetic: 4
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 996
Molecular Weight (Da) 114,709
Isoelectric Point (pI) 7.49
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:1023212 to 1020222 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2991 1023212..1020222 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005890
References cited on this page View Complete Literature Guide for PIP2
1) Rottensteiner H, et al.  (1996) Pip2p: a transcriptional regulator of peroxisome proliferation in the yeast Saccharomyces cerevisiae. EMBO J 15(12):2924-34
2) Karpichev IV, et al.  (1997) A complex containing two transcription factors regulates peroxisome proliferation and the coordinate induction of beta-oxidation enzymes in Saccharomyces cerevisiae. Mol Cell Biol 17(1):69-80
3) Rottensteiner H, et al.  (1997) A heterodimer of the Zn2Cys6 transcription factors Pip2p and Oaf1p controls induction of genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Eur J Biochem 247(3):776-83
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61