Standard Name	PIN4 1
Systematic Name	YBL051C
Alias	MDT1
Feature Type	ORF, Verified
Description	Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage (2)
Name Description	Psi+ INducibility 1

Chromosomal Location	ChrII:124759 to 122753 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PIN4
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	DNA damage checkpoint (IGI, IPI) G2/M transition of mitotic cell cycle (IMP)
Cellular Component
High-throughput	cytoplasm (IDA)

Classical genetics
null	cold sensitivity: increased resistance to bleomycin A2: decreased
Large-scale survey
null	cell size: increased glycogen accumulation: increased competitive fitness: decreased dessication resistance: decreased haploinsufficient hyperosmotic stress resistance: decreased oxidative stress resistance: decreased protein transport: abnormal resistance to cycloheximide: decreased resistance to sirolimus: decreased resistance to wortmannin: decreased resistance to ethanol: decreased resistance to nickel sulfate: decreased resistance to arsenite(3-): decreased resistance to sodium arsenite: decreased resistance to L-canavanine: increased resistance to dimethyl sulfoxide: increased resistance to hygromycin B: decreased resistance to doxorubicin: decreased resistance to benzo[a]pyrene: decreased toxin resistance: decreased vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	108 total interaction(s) for 93 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 3 Affinity Capture-Western: 1 PCA: 5 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 45 Phenotypic Enhancement: 9 Phenotypic Suppression: 3 Positive Genetic: 9 Synthetic Growth Defect: 13 Synthetic Lethality: 5 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:124759 to 122753 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2007 124759..122753 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000147