PIN4/YBL051C Summary Help

Standard Name PIN4 1
Systematic Name YBL051C
Alias MDT1
Feature Type ORF, Verified
Description Protein involved in G2/M phase progression and response to DNA damage; interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage (2)
Name Description Psi+ INducibility 1
Chromosomal Location
ChrII:124759 to 122753 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PIN4 GO evidence and references
  View Computational GO annotations for PIN4
Molecular Function
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
repressible
Resources
109 total interaction(s) for 92 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 1
  • PCA: 5
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 3
  • Negative Genetic: 45
  • Phenotypic Enhancement: 9
  • Phenotypic Suppression: 3
  • Positive Genetic: 9
  • Synthetic Growth Defect: 13
  • Synthetic Lethality: 5
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 668
Molecular Weight (Da) 73,775
Isoelectric Point (pI) 6.21
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:124759 to 122753 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2007 124759..122753 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000147
References cited on this page View Complete Literature Guide for PIN4
1) Derkatch IL, et al.  (2001) Prions affect the appearance of other prions: the story of [PIN(+)]. Cell 106(2):171-82
2) Pike BL, et al.  (2004) Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae. Mol Cell Biol 24(7):2779-88