Standard Name	PIH1 1
Systematic Name	YHR034C
Alias	NOP17 2
Feature Type	ORF, Verified
Description	Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II (1, 2, 3, 4, 5, 6)
Name Description	Protein Interacting with Hsp90 1

Chromosomal Location	ChrVIII:177999 to 176965 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PIH1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	box C/D snoRNP assembly (IMP) protein folding (IGI, IMP, IPI) rRNA processing (IGI, IMP, IPI)
High-throughput	regulation of cell size (IMP)
Cellular Component
Manually curated	R2TP complex (IDA, IPI) small nucleolar ribonucleoprotein complex (IPI)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	snR17a/b snoRNA accumulation: decreased heat sensitivity: increased resistance to 5-fluorouracil: decreased resistance to tellurite: decreased
Large-scale survey
null	cell size: decreased competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate heat sensitivity: increased resistance to camptothecin: increased resistance to bleomycin: increased resistance to wortmannin: increased resistance to hydroxyurea: increased resistance to methyl methanesulfonate: increased resistance to mycophenolic acid: increased resistance to tunicamycin: increased resistance to sirolimus: decreased resistance to 5-fluorouracil: decreased resistance to cycloheximide: decreased resistance to fluconazole: increased stress resistance: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	156 total interaction(s) for 99 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-RNA: 1 Affinity Capture-Western: 12 Co-fractionation: 1 PCA: 1 Reconstituted Complex: 7 Two-hybrid: 23
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 57 Positive Genetic: 26 Synthetic Growth Defect: 16 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:177999 to 176965 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1035 177999..176965 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001076