Standard Name	PHO86
Systematic Name	YJL117W
Feature Type	ORF, Verified
Description	Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress (1, 2)
Name Description	PHOsphate metabolism

Chromosomal Location	ChrX:192531 to 193466 | ORF Map | GBrowse

	View Computational GO annotations for PHO86
Molecular Function
Manually curated	unfolded protein binding (IMP)
Biological Process
Manually curated	ER to Golgi vesicle-mediated transport (IMP) protein folding (IMP) regulation of phosphate transport (IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA)

Classical genetics
null	metal resistance: decreased resistance to disodium selenite: decreased resistance to quinine: decreased
overexpression	acid phosphatase activity: increased
Large-scale survey
null	alkaline pH resistance: decreased auxotrophy competitive fitness: decreased haploinsufficient heat sensitivity: increased hyperosmotic stress resistance: decreased metal resistance: decreased oxidative stress resistance: decreased resistance to fluconazole: increased resistance to tunicamycin: increased resistance to nickel sulfate: decreased resistance to dihydromotuporamine C: decreased resistance to propolis extract: decreased resistance to quinine: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to cycloheximide: decreased resistance to fenpropimorph: decreased resistance to sodium selenide: decreased resistance to chloroquine: decreased resistance to mefloquine: decreased resistance to clioquinol: decreased resistance to calcium dichloride: decreased resistance to curcumin: decreased resistance to methyl methanesulfonate: increased respiratory growth: decreased rate sporulation: decreased stress resistance: increased utilization of carbon source: decreased utilization of iron source: decreased utilization of phosphorus source: decreased vacuolar morphology: abnormal vegetative growth: increased rate viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	171 total interaction(s) for 125 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Biochemical Activity: 1 PCA: 42 Two-hybrid: 5
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 85 Phenotypic Enhancement: 5 Positive Genetic: 10 Synthetic Growth Defect: 8 Synthetic Lethality: 4 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:192531 to 193466 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..936 192531..193466 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003653