PHO86/YJL117W Summary Help

Standard Name PHO86
Systematic Name YJL117W
Feature Type ORF, Verified
Description Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress (1, 2)
Name Description PHOsphate metabolism
Chromosomal Location
ChrX:192531 to 193466 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PHO86 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 9 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
198 total interaction(s) for 138 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Biochemical Activity: 1
  • PCA: 43
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 109
  • Phenotypic Enhancement: 5
  • Positive Genetic: 11
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 4
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 311
Molecular Weight (Da) 34,881
Isoelectric Point (pI) 10.44
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:192531 to 193466 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..936 192531..193466 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003653
References cited on this page View Complete Literature Guide for PHO86
1) Lau WT, et al.  (2000) Pho86p, an endoplasmic reticulum (ER) resident protein in Saccharomyces cerevisiae, is required for ER exit of the high-affinity phosphate transporter Pho84p. Proc Natl Acad Sci U S A 97(3):1107-12
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76