Standard Name	PHO8
Systematic Name	YDR481C
Feature Type	ORF, Verified
Description	Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN (1, 2, 3) Also known as: phoH 4
Name Description	PHOsphate metabolism

Chromosomal Location	ChrIV:1420250 to 1418550 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 306 cM

	View Computational GO annotations for PHO8
Molecular Function
Manually curated	alkaline phosphatase activity (IDA) nucleotide phosphatase activity (IDA)
Biological Process
Manually curated	nicotinamide nucleotide metabolic process (IMP) protein dephosphorylation (IDA)
Cellular Component
Manually curated	fungal-type vacuole membrane (IDA)

Classical genetics
null	N-ribosylnicotinamide accumulation: decreased
Large-scale survey
null	competitive fitness: decreased resistance to sodium selenide: decreased starvation resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	22 total interaction(s) for 21 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 3 Affinity Capture-Western: 2 Co-fractionation: 3 Protein-RNA: 1 Reconstituted Complex: 1
Genetic Interactions	Negative Genetic: 6 Phenotypic Enhancement: 1 Positive Genetic: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1420250 to 1418550 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 306 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1701 1420250..1418550 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002889