Standard Name	PHO23
Systematic Name	YNL097C
Feature Type	ORF, Verified
Description	Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3 (1, 2, 3, 4, 5)
Name Description	PHOsphate metabolism

Chromosomal Location	ChrXIV:442358 to 441366 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PHO23
Molecular Function
Manually curated	methylated histone residue binding (IDA)
Biological Process
Manually curated	chromatin modification (IMP, IPI, ISS) negative regulation of chromatin silencing at rDNA (IMP) negative regulation of chromatin silencing at silent mating-type cassette (IMP) negative regulation of chromatin silencing at telomere (IMP) negative regulation of transcription from RNA polymerase I promoter (IMP) positive regulation of transcription from RNA polymerase II promoter (IMP) positive regulation of transcription from RNA polymerase II promoter in response to heat stress (IMP)
Cellular Component
Manually curated	histone deacetylase complex (IDA) Rpd3L complex (IDA)
High-throughput	nucleus (IDA) Rpd3L complex (IDA) Rpd3L-Expanded complex (IDA)

Classical genetics
null	RPR2 cryptic unstable transcript accumulation: increased snR3 accumulation: abnormal inositol excretion: increased GFP-Rap1 distribution: abnormal histone H4 modification: increased resistance to camptothecin: decreased resistance to cycloheximide: decreased viable
overexpression	vegetative growth: normal
Large-scale survey
null	inositol excretion: increased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased filamentous growth: decreased haploinsufficient heat sensitivity: increased invasive growth: absent mutation frequency: decreased resistance to mycophenolic acid: decreased resistance to propolis extract: decreased resistance to sodium arsenite: decreased resistance to cycloheximide: decreased resistance to arsenite(3-): decreased resistance to sulfanilamide: decreased resistance to wortmannin: decreased resistance to methyl methanesulfonate: increased resistance to hydroxyurea: increased resistance to fluconazole: increased resistance to camptothecin: increased resistance to bleomycin: increased resistance to sirolimus: increased resistance to tunicamycin: decreased resistance to BPS: decreased resistance to calcium dichloride: decreased resistance to doxorubicin: decreased respiratory growth: decreased rate sporulation efficiency: increased starvation resistance: decreased stress resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	952 total interaction(s) for 509 unique genes/features.
Physical Interactions	Affinity Capture-Luminescence: 4 Affinity Capture-MS: 53 Affinity Capture-RNA: 1 Affinity Capture-Western: 14 Biochemical Activity: 2 Co-localization: 1 Reconstituted Complex: 1 Two-hybrid: 3
Genetic Interactions	Dosage Growth Defect: 3 Negative Genetic: 595 Phenotypic Enhancement: 15 Phenotypic Suppression: 11 Positive Genetic: 133 Synthetic Growth Defect: 84 Synthetic Lethality: 19 Synthetic Rescue: 13
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:442358 to 441366 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	This feature contains embedded feature(s): YNL097W-A
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..993 442358..441366 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005041