PHO12/YHR215W Summary Help

Standard Name PHO12
Systematic Name YHR215W
Alias PHO10
Feature Type ORF, Verified
Description One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that arose from a segmental duplication (1, 2, 3, 4)
Name Description PHOsphate metabolism
Chromosomal Location
ChrVIII:552099 to 553502 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PHO12 GO evidence and references
  View Computational GO annotations for PHO12
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 24 genes
Resources
Large-scale survey
null
Resources
7 total interaction(s) for 7 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 467
Molecular Weight (Da) 52,699
Isoelectric Point (pI) 4.85
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:552099 to 553502 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1404 552099..553502 2005-11-07 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001258
References cited on this page View Complete Literature Guide for PHO12
1) Praetorius-Ibba M, et al.  (1997) Homologous recombination partly restores the secretion defect of underglycosylated acid phosphatase in yeast. Curr Genet 32(3):190-6
2) Venter U and Horz W  (1989) The acid phosphatase genes PHO10 and PHO11 in S. cerevisiae are located at the telomeres of chromosomes VIII and I. Nucleic Acids Res 17(4):1353-69
3) Blinnikova EI, et al.  (2002) Vesicular transport of extracellular acid phosphatases in yeast Saccharomyces cerevisiae. Biochemistry (Mosc) 67(4):485-90
4) Katju V, et al.  (2009) Variation in gene duplicates with low synonymous divergence in Saccharomyces cerevisiae relative to Caenorhabditis elegans. Genome Biol 10(7):R75