PHB1/YGR132C Summary Help

Standard Name PHB1
Systematic Name YGR132C
Feature Type ORF, Verified
Description Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR) (1, 2, 3, 4, 5, 6)
Name Description ProHiBitin
Chromosomal Location
ChrVII:756452 to 755589 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PHB1 GO evidence and references
  View Computational GO annotations for PHB1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 10 genes
Resources
Classical genetics
null
repressible
Large-scale survey
null
overexpression
unspecified
Resources
212 total interaction(s) for 136 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 22
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 7
  • Co-fractionation: 1
  • PCA: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 2
  • Negative Genetic: 90
  • Phenotypic Enhancement: 1
  • Positive Genetic: 26
  • Synthetic Growth Defect: 30
  • Synthetic Lethality: 24
  • Synthetic Rescue: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 287
Molecular Weight (Da) 31,427
Isoelectric Point (pI) 8.93
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:756452 to 755589 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..864 756452..755589 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003364
References cited on this page View Complete Literature Guide for PHB1
1) Coates PJ, et al.  (1997) The prohibitin family of mitochondrial proteins regulate replicative lifespan. Curr Biol 7(8):607-10
2) Berger KH and Yaffe MP  (1998) Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae. Mol Cell Biol 18(7):4043-52
3) Nijtmans LG, et al.  (2000) Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins. EMBO J 19(11):2444-51
4) Piper PW, et al.  (2002) The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells. Aging Cell 1(2):149-57
5) Tatsuta T, et al.  (2005) Formation of membrane-bound ring complexes by prohibitins in mitochondria. Mol Biol Cell 16(1):248-59
6) Schleit J, et al.  (2013) Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell 12(6):1050-1061