PFA5/YDR459C Summary Help

Standard Name PFA5 1, 2
Systematic Name YDR459C
Feature Type ORF, Verified
Description Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain (2, 3, 4, 5)
Name Description Protein Fatty Acyltransferase 1
Chromosomal Location
ChrIV:1383443 to 1382319 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PFA5 GO evidence and references
  View Computational GO annotations for PFA5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Large-scale survey
null
overexpression
Resources
17 total interaction(s) for 17 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 1
  • PCA: 4

Genetic Interactions
  • Negative Genetic: 5
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 374
Molecular Weight (Da) 42,922
Isoelectric Point (pI) 8.32
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1383443 to 1382319 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1125 1383443..1382319 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002867
References cited on this page View Complete Literature Guide for PFA5
1) Smotrys J, et al.  (2005) personal communication
2) Mitchell DA, et al.  (2006) Protein palmitoylation by a family of DHHC protein S-acyltransferases. J Lipid Res 47(6):1118-27
3) Bartels DJ, et al.  (1999) Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae. Mol Cell Biol 19(10):6775-87
4) Valdez-Taubas J and Pelham H  (2005) Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation. EMBO J 24(14):2524-32
5) Smotrys JE, et al.  (2005) The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p. J Cell Biol 170(7):1091-9