Standard Name	PFA4 1, 2
Systematic Name	YOL003C
Feature Type	ORF, Verified
Description	Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases (2, 3, 4, 5)
Name Description	Protein Fatty Acyltransferase 1

Chromosomal Location	ChrXV:322994 to 321858 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PFA4
Molecular Function
Manually curated	palmitoyltransferase activity (IMP)
Biological Process
Manually curated	protein palmitoylation (IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	Chs3p modification: decreased Tat1p modification: absent Agp1p modification: absent Hip1p modification: absent Bap2p modification: absent Tat2p modification: absent Gnp1p modification: absent resistance to calcofluor white: increased
unspecified	chitin deposition: decreased Chs3p modification: decreased
Large-scale survey
null	chitin deposition: decreased competitive fitness: decreased competitive fitness: increased haploinsufficient heat sensitivity: increased resistance to amitrole: decreased resistance to cycloheximide: decreased resistance to wortmannin: normal resistance to sirolimus: decreased resistance to benzo[a]pyrene: decreased starvation resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	64 total interaction(s) for 55 unique genes/features.
Physical Interactions	Affinity Capture-Western: 1 Biochemical Activity: 1 PCA: 10 Two-hybrid: 3
Genetic Interactions	Negative Genetic: 36 Phenotypic Enhancement: 3 Phenotypic Suppression: 1 Synthetic Growth Defect: 5 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:322994 to 321858 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1137 322994..321858 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005363