PEX8/YGR077C Summary Help

Standard Name PEX8 1, 2
Systematic Name YGR077C
Alias PAS6
Feature Type ORF, Verified
Description Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p (1, 3, 4)
Name Description PEroXin 2
Chromosomal Location
ChrVII:639513 to 637744 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PEX8 GO evidence and references
  View Computational GO annotations for PEX8
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
unspecified
Resources
82 total interaction(s) for 67 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Co-fractionation: 3
  • PCA: 1
  • Protein-RNA: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Lethality: 2
  • Negative Genetic: 37
  • Positive Genetic: 7
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 589
Molecular Weight (Da) 68,165
Isoelectric Point (pI) 7.62
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:639513 to 637744 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1770 639513..637744 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003309
References cited on this page View Complete Literature Guide for PEX8
1) Rehling P, et al.  (2000) Pex8p, an intraperoxisomal peroxin of Saccharomyces cerevisiae required for protein transport into peroxisomes binds the PTS1 receptor pex5p. J Biol Chem 275(5):3593-602
2) Distel B, et al.  (1996) A unified nomenclature for peroxisome biogenesis factors. J Cell Biol 135(1):1-3
3) Agne B, et al.  (2003) Pex8p: an intraperoxisomal organizer of the peroxisomal import machinery. Mol Cell 11(3):635-46
4) Deckers M, et al.  (2010) Targeting of Pex8p to the peroxisomal importomer. Eur J Cell Biol 89(12):924-31