Standard Name	PET54 1
Systematic Name	YGR222W
Feature Type	ORF, Verified
Description	Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing (1, 2, 3, 4)
Name Description	PETite colonies

Chromosomal Location	ChrVII:939923 to 940804 | ORF Map | GBrowse
	Genetic position: 174 cM

	View Computational GO annotations for PET54
Molecular Function
Manually curated	RNA binding (IDA) translation regulator activity (IMP)
Biological Process
Manually curated	Group I intron splicing (IDA, IGI) mitochondrial respiratory chain complex IV biogenesis (IMP) positive regulation of mitochondrial translation (IMP)
Cellular Component
Manually curated	extrinsic to mitochondrial inner membrane (IDA) mitochondrial inner membrane (IDA) mitochondrial matrix (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	petite Cox3p accumulation: absent respiratory growth: absent
Large-scale survey
null	glycogen accumulation: decreased competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased resistance to acrolein: decreased resistance to elesclomol-Cu: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased respiratory growth: absent respiratory growth: decreased rate starvation resistance: decreased vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	23 total interaction(s) for 19 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Protein-RNA: 2 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 5 Phenotypic Suppression: 1 Positive Genetic: 3 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:939923 to 940804 | ORF Map | GBrowse
	Genetic position: 174 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..882 939923..940804 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003454