PER33/YLR064W Summary Help

Standard Name PER33 1
Systematic Name YLR064W
Feature Type ORF, Verified
Description Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5, 6)
Name Description Pore and ER protein, 33 kDa 1
Chromosomal Location
ChrXII:265456 to 266277 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PER33 GO evidence and references
  View Computational GO annotations for PER33
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 8 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
46 total interaction(s) for 37 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 3
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 19
  • Phenotypic Enhancement: 2
  • Positive Genetic: 8
  • Synthetic Growth Defect: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 273
Molecular Weight (Da) 32,637
Isoelectric Point (pI) 10.94
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:265456 to 266277 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..822 265456..266277 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004054
References cited on this page View Complete Literature Guide for PER33
1) CHADRIN A, et al.  (2010) Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution. J Cell Biol 189(5):795-811
2) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Heinicke S, et al.  (2007) The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists. PLoS One 2(8):e766
5) Burtner CR, et al.  (2011) A genomic analysis of chronological longevity factors in budding yeast. Cell Cycle 10(9):1385-96
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76