PDS5/YMR076C Summary Help

Standard Name PDS5 1
Systematic Name YMR076C
Feature Type ORF, Verified
Description Protein involved in sister chromatid condensation and cohesion; colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis; relocalizes to the cytosol in response to hypoxia (1, 2, 3, 4)
Name Description Precocious Dissociation of Sisters 1
Chromosomal Location
ChrXIII:420029 to 416196 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PDS5 GO evidence and references
  View Computational GO annotations for PDS5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
conditional
repressible
Large-scale survey
null
reduction of function
repressible
Resources
74 total interaction(s) for 50 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 20
  • Affinity Capture-Western: 12
  • Biochemical Activity: 1
  • FRET: 2
  • Two-hybrid: 24

Genetic Interactions
  • Dosage Rescue: 4
  • Positive Genetic: 1
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 5
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,277
Molecular Weight (Da) 147,040
Isoelectric Point (pI) 6.2
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:420029 to 416196 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3834 420029..416196 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004681
References cited on this page View Complete Literature Guide for PDS5
1) Hartman T, et al.  (2000) Pds5p is an essential chromosomal protein required for both sister chromatid cohesion and condensation in Saccharomyces cerevisiae. J Cell Biol 151(3):613-26
2) Panizza S, et al.  (2000) Pds5 cooperates with cohesin in maintaining sister chromatid cohesion. Curr Biol 10(24):1557-64
3) Zhang Z, et al.  (2005) Budding yeast PDS5 plays an important role in meiosis and is required for sister chromatid cohesion. Mol Microbiol 56(3):670-80
4) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30