PDR8/YLR266C Summary Help

Standard Name PDR8 1
Systematic Name YLR266C
Feature Type ORF, Verified
Description Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication (1, 2)
Name Description Pleiotropic Drug Resistance 1
Chromosomal Location
ChrXII:677724 to 675619 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PDR8 GO evidence and references
  View Computational GO annotations for PDR8
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 5 genes
Regulators 18 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
33 total interaction(s) for 33 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 28
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 701
Molecular Weight (Da) 81,273
Isoelectric Point (pI) 6.8
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:677724 to 675619 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2106 677724..675619 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004256
References cited on this page View Complete Literature Guide for PDR8
1) Hikkel I, et al.  (2003) A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast. J Biol Chem 278(13):11427-32
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87