PDR17/YNL264C Summary Help

Standard Name PDR17 1
Systematic Name YNL264C
Alias ISS1 2 , SFH4 3
Feature Type ORF, Verified
Description Phosphatidylinositol transfer protein (PITP); downregulates Plb1p-mediated turnover of phosphatidylcholine; forms a complex with Psd2p which appears essential for maintenance of vacuolar PE levels; found in the cytosol and microsomes; homologous to Pdr16p; deletion affects phospholipid composition (1, 3, 4, 5)
Name Description Pleiotropic Drug Resistance 1
Chromosomal Location
ChrXIV:146615 to 145563 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PDR17 GO evidence and references
  View Computational GO annotations for PDR17
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
59 total interaction(s) for 47 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • PCA: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 6
  • Negative Genetic: 28
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 350
Molecular Weight (Da) 40,677
Isoelectric Point (pI) 7.21
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:146615 to 145563 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1053 146615..145563 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005208
References cited on this page View Complete Literature Guide for PDR17
1) van den Hazel HB, et al.  (1999) PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs. J Biol Chem 274(4):1934-41
2) Entian KD, et al.  (1999) Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Mol Gen Genet 262(4-5):683-702
3) Li X, et al.  (2000) Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth. Mol Biol Cell 11(6):1989-2005
4) Schnabl M, et al.  (2003) Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover. Eur J Biochem 270(15):3133-45
5) Gulshan K, et al.  (2010) Compartment-specific Synthesis of Phosphatidylethanolamine Is Required for Normal Heavy Metal Resistance. Mol Biol Cell 21(3):443-55