PDE1/YGL248W Summary Help

Standard Name PDE1 1
Systematic Name YGL248W
Feature Type ORF, Verified
Description Low-affinity cyclic AMP phosphodiesterase; controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation (1, 2, 3, 4, 5)
Name Description PhosphoDiEsterase 1
Chromosomal Location
ChrVII:35653 to 36762 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PDE1 GO evidence and references
  View Computational GO annotations for PDE1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 67 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
33 total interaction(s) for 26 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 2

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 13
  • Phenotypic Enhancement: 2
  • Positive Genetic: 5
  • Synthetic Growth Defect: 4
  • Synthetic Haploinsufficiency: 1
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 369
Molecular Weight (Da) 42,016
Isoelectric Point (pI) 6.08
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:35653 to 36762 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1110 35653..36762 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003217
References cited on this page View Complete Literature Guide for PDE1
1) Uno I, et al.  (1983) Characterization of a cyclic nucleotide phosphodiesterase-deficient mutant in yeast. J Biol Chem 258(6):3539-42
2) Nikawa J, et al.  (1987) Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae. Mol Cell Biol 7(10):3629-36
3) Thevelein JM and de Winde JH  (1999) Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol Microbiol 33(5):904-18
4) Ma P, et al.  (1999) The PDE1-encoded low-affinity phosphodiesterase in the yeast Saccharomyces cerevisiae has a specific function in controlling agonist-induced cAMP signaling. Mol Biol Cell 10(1):91-104
5) Wera S, et al.  (1997) Glucose exerts opposite effects on mRNA versus protein and activity levels of Pde1, the low-affinity cAMP phosphodiesterase from budding yeast, Saccharomyces cerevisiae. FEBS Lett 420(2-3):147-50