PDC2/YDR081C Summary Help

Standard Name PDC2 1
Systematic Name YDR081C
Feature Type ORF, Verified
Description Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions (2, 3, 4, 5, 6, 7, 8)
Name Description Pyruvate DeCarboxylase 1
Chromosomal Location
ChrIV:610081 to 607304 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 50 cM
Gene Ontology Annotations All PDC2 GO evidence and references
  View Computational GO annotations for PDC2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Classical genetics
reduction of function
Large-scale survey
10 total interaction(s) for 9 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 925
Molecular Weight (Da) 103,943
Isoelectric Point (pI) 6.4
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:610081 to 607304 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 50 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2778 610081..607304 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002488
References cited on this page View Complete Literature Guide for PDC2
1) Schmitt HD and Zimmermann FK  (1982) Genetic analysis of the pyruvate decarboxylase reaction in yeast glycolysis. J Bacteriol 151(3):1146-52
2) Velmurugan S, et al.  (1997) Suppression of pdc2 regulating pyruvate decarboxylase synthesis in yeast. Genetics 145(3):587-94
3) Hohmann S and Meacock PA  (1998) Thiamin metabolism and thiamin diphosphate-dependent enzymes in the yeast Saccharomyces cerevisiae: genetic regulation. Biochim Biophys Acta 1385(2):201-19
4) Hohmann S  (1993) Characterisation of PDC2, a gene necessary for high level expression of pyruvate decarboxylase structural genes in Saccharomyces cerevisiae. Mol Gen Genet 241(5-6):657-66
5) Mojzita D and Hohmann S  (2006) Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mol Genet Genomics 276(2):147-61
6) Nosaka K, et al.  (2008) Thiamin-dependent transactivation activity of PDC2 in Saccharomyces cerevisiae. FEBS Lett 582(29):3991-6
7) Raghuram V, et al.  (1994) PDC2, a yeast gene essential for synthesis of pyruvate decarboxylase, encodes a novel transcription factor J Genet 73():17-32
8) Nosaka K, et al.  (2012) Facilitated recruitment of Pdc2p, a yeast transcriptional activator, in response to thiamin starvation. FEMS Microbiol Lett 330(2):140-7