PCP1/YGR101W Summary

PCP1 BASIC INFORMATION

Standard Name	PCP1
Systematic Name	YGR101W
Alias	MDM37 , RBD1
Feature Type	ORF, Verified
Description	Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases (1, 2, 3)
Name Description	Processing of Cytochrome c Peroxidase 1

GO Annotations	All PCP1 GO evidence and references
	View Computational GO annotations for PCP1
Molecular Function
Manually curated	peptidase activity (IMP, ISS)
Biological Process
Manually curated	mitochondrion organization (IMP) protein import into mitochondrial intermembrane space (TAS) signal peptide processing (IMP)
Cellular Component
Manually curated	mitochondrion (TAS)

Mutant Phenotype	All PCP1 Phenotype details and references
Classical genetics
null	Mgm1p modification: abnormal
Large-scale survey
null	glycogen accumulation: decreased competitive fitness: decreased hyperosmotic stress resistance: decreased mitochondrial morphology: abnormal resistance to hygromycin B: decreased resistance to farnesol: decreased resistance to pyocyanin: increased respiratory growth: decreased rate respiratory growth: absent telomere length: decreased utilization of carbon source: decreased viable

Interactions	PCP1 All interactions details and references
	9 total interaction(s) for 8 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Biochemical Activity: 2 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 1 Synthetic Growth Defect: 2 Synthetic Rescue: 1

Sequence Information

ChrVII:693367 to 694407 | |

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1041	693367..694407	2004-07-20	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003333

PCP1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PCP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PCP1]

1)	Esser K, et al. (2002) A novel two-step mechanism for removal of a mitochondrial signal sequence involves the mAAA complex and the putative rhomboid protease Pcp1. J Mol Biol 323(5):835-43
2)	Herlan M, et al. (2003) Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem 278(30):27781-8
3)	Sesaki H, et al. (2003) Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusion. Biochem Biophys Res Commun 308(2):276-83

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