PCL5/YHR071W Summary Help

PCL5 BASIC INFORMATION

Standard Name PCL5
Systematic Name YHR071W
Feature Type ORF, Verified
Description Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity (1, 2, 3)
Name Description Pho85 CycLin 1
GO Annotations All PCL5 GO evidence and references
    View Computational GO annotations for PCL5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All PCL5 Phenotype details and references
Classical genetics
reduction of function
Interactions PCL5 All interactions details and references
  View additional details at BioGRID
12 total interaction(s) for 9 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 2
  • Biochemical Activity: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 1
Genetic Interactions
  • Negative Genetic: 1
  • Phenotypic Enhancement: 3
  • Positive Genetic: 2
  • Synthetic Rescue: 1
Sequence Information
ChrVIII:237006 to 237695 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..690 237006..237695 2005-11-07 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001113

PCL5 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for PCL5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PCL5]

1) Measday V, et al.  (1997) A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase. Mol Cell Biol 17(3):1212-23
2) Shemer R, et al.  (2002) Regulation of the transcription factor Gcn4 by Pho85 cyclin PCL5. Mol Cell Biol 22(15):5395-404
3) Aviram S, et al.  (2008) Autophosphorylation-induced degradation of the Pho85 cyclin Pcl5 is essential for response to amino acid limitation. Mol Cell Biol 28(22):6858-69