PCI8/YIL071C Summary Help

Standard Name PCI8 1
Systematic Name YIL071C
Alias YIH1 , CSN11 , YIL071W
Feature Type ORF, Verified
Description Possible shared subunit of Cop9 signalosome (CSN) and eIF3; binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain (1, 2)
Name Description Proteasome-COP9 signalosome (CSN)-eIF3 1
Chromosomal Location
ChrIX:229994 to 228660 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PCI8 GO evidence and references
  View Computational GO annotations for PCI8
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
57 total interaction(s) for 36 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 23
  • Affinity Capture-Western: 4
  • Reconstituted Complex: 2

Genetic Interactions
  • Negative Genetic: 26
  • Positive Genetic: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 444
Molecular Weight (Da) 51,287
Isoelectric Point (pI) 4.59
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:229994 to 228660 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1335 229994..228660 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001333
References cited on this page View Complete Literature Guide for PCI8
1) Shalev A, et al.  (2001) Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits. J Biol Chem 276(37):34948-57
2) Maytal-Kivity V, et al.  (2002) COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. EMBO Rep 3(12):1215-21