PCD1/YLR151C Summary Help

Standard Name PCD1 1
Systematic Name YLR151C
Feature Type ORF, Verified
Description 8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1 (1, 2, 3)
Name Description Peroxisomal Coenzyme A Diphosphatase 1
Chromosomal Location
ChrXII:442737 to 441715 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PCD1 GO evidence and references
  View Computational GO annotations for PCD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
null
Large-scale survey
null
Resources
13 total interaction(s) for 13 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 3

Genetic Interactions
  • Negative Genetic: 6
  • Positive Genetic: 3
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 340
Molecular Weight (Da) 39,754
Isoelectric Point (pI) 6.59
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:442737 to 441715 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1023 442737..441715 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004141
References cited on this page View Complete Literature Guide for PCD1
1) Cartwright JL, et al.  (2000) The Saccharomyces cerevisiae PCD1 gene encodes a peroxisomal nudix hydrolase active toward coenzyme A and its derivatives. J Biol Chem 275(42):32925-30
2) Nunoshiba T, et al.  (2004) A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c (PCD1 gene) in Saccharomyces cerevisiae. Nucleic Acids Res 32(18):5339-48
3) Song MG, et al.  (2013) Multiple Nudix family proteins possess mRNA decapping activity. RNA 19(3):390-9