PCC1/YKR095W-A Summary Help

Standard Name PCC1 1
Systematic Name YKR095W-A
Feature Type ORF, Verified
Description Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; other complex members are Kae1p, Gon7p, Bud32p, and Cgi121p (1, 2, 3)
Name Description Polarized growth Chromatin-associated Controller 1
Chromosomal Location
ChrXI:625864 to 626205 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PCC1 GO evidence and references
  View Computational GO annotations for PCC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 41 genes
Resources
Classical genetics
conditional
null
Resources
16 total interaction(s) for 14 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 2
  • Far Western: 1
  • Reconstituted Complex: 2

Genetic Interactions
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 5

Resources
Length (a.a.) 88
Molecular Weight (Da) 9,992
Isoelectric Point (pI) 5.19
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:625864 to 626205 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2004-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..38 625864..625901 2011-02-03 2004-01-28
Intron 39..113 625902..625976 2011-02-03 2004-01-28
CDS 114..342 625977..626205 2011-02-03 2004-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000028512
References cited on this page View Complete Literature Guide for PCC1
1) Kisseleva-Romanova E, et al.  (2006) Yeast homolog of a cancer-testis antigen defines a new transcription complex. EMBO J 25(15):3576-85
2) Srinivasan M, et al.  (2011) The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. EMBO J 30(5):873-81
3) Daugeron MC, et al.  (2011) Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs. Nucleic Acids Res 39(14):6148-60