PCC1/YKR095W-A Summary Help

Standard Name PCC1 1
Systematic Name YKR095W-A
Feature Type ORF, Verified
Description Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; other complex members are Kae1p, Gon7p, Bud32p, and Cgi121p (1, 2, 3, 4)
Name Description Polarized growth Chromatin-associated Controller 1
Chromosomal Location
ChrXI:625864 to 626205 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PCC1 GO evidence and references
  View Computational GO annotations for PCC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
conditional
null
Resources
16 total interaction(s) for 14 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 2
  • Far Western: 1
  • Reconstituted Complex: 2

Genetic Interactions
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 5

Resources
Length (a.a.) 88
Molecular Weight (Da) 9,992
Isoelectric Point (pI) 5.19
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:625864 to 626205 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2004-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..38 625864..625901 2011-02-03 2004-01-28
Intron 39..113 625902..625976 2011-02-03 2004-01-28
CDS 114..342 625977..626205 2011-02-03 2004-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000028512
References cited on this page View Complete Literature Guide for PCC1
1) Kisseleva-Romanova E, et al.  (2006) Yeast homolog of a cancer-testis antigen defines a new transcription complex. EMBO J 25(15):3576-85
2) Srinivasan M, et al.  (2011) The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. EMBO J 30(5):873-81
3) Daugeron MC, et al.  (2011) Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs. Nucleic Acids Res 39(14):6148-60
4) Hu Y, et al.  (2013) Telomerase-null survivor screening identifies novel telomere recombination regulators. PLoS Genet 9(1):e1003208