PBP1/YGR178C Summary Help

Standard Name PBP1 1
Systematic Name YGR178C
Alias MRS16
Feature Type ORF, Verified
Description Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress (1, 2, 3, 4, 5, 6)
Name Description Pab1p-Binding Protein 1
Chromosomal Location
ChrVII:853215 to 851047 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PBP1 GO evidence and references
  View Computational GO annotations for PBP1
Molecular Function
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
unspecified
Resources
182 total interaction(s) for 126 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 32
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 6
  • PCA: 4
  • Two-hybrid: 22

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 84
  • Phenotypic Enhancement: 1
  • Positive Genetic: 18
  • Synthetic Growth Defect: 6
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 722
Molecular Weight (Da) 78,781
Isoelectric Point (pI) 6.91
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:853215 to 851047 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2169 853215..851047 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003410
References cited on this page View Complete Literature Guide for PBP1
1) Mangus DA, et al.  (1998) Pbp1p, a factor interacting with Saccharomyces cerevisiae poly(A)-binding protein, regulates polyadenylation. Mol Cell Biol 18(12):7383-96
2) Mangus DA, et al.  (2004) Identification of factors regulating poly(A) tail synthesis and maturation. Mol Cell Biol 24(10):4196-206
3) Tadauchi T, et al.  (2004) Posttranscriptional regulation of HO expression by the Mkt1-Pbp1 complex. Mol Cell Biol 24(9):3670-81
4) Ralser M, et al.  (2005) An integrative approach to gain insights into the cellular function of human ataxin-2. J Mol Biol 346(1):203-14
5) Buchan JR, et al.  (2008) P bodies promote stress granule assembly in Saccharomyces cerevisiae. J Cell Biol 183(3):441-55
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76