PBP1/YGR178C Summary Help

PBP1 BASIC INFORMATION

Standard Name PBP1 1
Systematic Name YGR178C
Alias MRS16
Feature Type ORF, Verified
Description Component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation (1, 2, 3, 4, 5)
Name Description Pab1p-Binding Protein 1
GO Annotations All PBP1 GO evidence and references
    View Computational GO annotations for PBP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All PBP1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
Interactions PBP1 All interactions details and references
58 total interaction(s) for 44 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 12
  • PCA: 4
  • Two-hybrid: 19
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 10
  • Synthetic Growth Defect: 4
  • Synthetic Rescue: 2
Sequence Information
ChrVII:853220 to 851052 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2169 853220..851052 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003410

PBP1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for PBP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PBP1]

1) Mangus DA, et al.  (1998) Pbp1p, a factor interacting with Saccharomyces cerevisiae poly(A)-binding protein, regulates polyadenylation. Mol Cell Biol 18(12):7383-96
2) Mangus DA, et al.  (2004) Identification of factors regulating poly(A) tail synthesis and maturation. Mol Cell Biol 24(10):4196-206
3) Tadauchi T, et al.  (2004) Posttranscriptional regulation of HO expression by the Mkt1-Pbp1 complex. Mol Cell Biol 24(9):3670-81
4) Ralser M, et al.  (2005) An integrative approach to gain insights into the cellular function of human ataxin-2. J Mol Biol 346(1):203-14
5) Buchan JR, et al.  (2008) P bodies promote stress granule assembly in Saccharomyces cerevisiae. J Cell Biol 183(3):441-55