PBN1/YCL052C Summary Help

Standard Name PBN1 1
Systematic Name YCL052C
Feature Type ORF, Verified
Description Component of glycosylphosphatidylinositol-mannosyltransferase I; essential component; required for the autocatalytic post-translational processing of the protease B precursor Prb1p; localizes to ER in lumenal orientation; homolog of mammalian PIG-X (1, 2)
Name Description Protease B Non-derepressible 1
Chromosomal Location
ChrIII:35393 to 34143 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PBN1 GO evidence and references
  View Computational GO annotations for PBN1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
conditional
Large-scale survey
conditional
null
overexpression
reduction of function
unspecified
Resources
31 total interaction(s) for 31 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 3
  • PCA: 12
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 4
  • Negative Genetic: 3
  • Positive Genetic: 5
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 416
Molecular Weight (Da) 47,923
Isoelectric Point (pI) 5.44
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:35393 to 34143 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2000-09-13 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1251 35393..34143 2000-09-13 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000557
References cited on this page View Complete Literature Guide for PBN1
1) Naik RR and Jones EW  (1998) The PBN1 gene of Saccharomyces cerevisiae: an essential gene that is required for the post-translational processing of the protease B precursor. Genetics 149(3):1277-92
2) Ashida H, et al.  (2005) Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I. Mol Biol Cell 16(3):1439-48