Standard Name	PAN3 1
Systematic Name	YKL025C
Alias	ECM35
Feature Type	ORF, Verified
Description	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes (1, 2, 3)
Name Description	Poly(A) Nuclease 1

Chromosomal Location	ChrXI:392279 to 390240 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PAN3
Molecular Function
Manually curated	contributes_to poly(A)-specific ribonuclease activity (IDA, IMP)
Biological Process
Manually curated	DNA repair (IDA) mRNA 3'-end processing (IMP, IPI) postreplication repair (IGI, IPI)
Cellular Component
Manually curated	PAN complex (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	cold sensitivity: increased vegetative growth: decreased viable
Large-scale survey
null	competitive fitness: increased resistance to caffeine: decreased resistance to bleomycin: increased resistance to fenpropimorph: increased resistance to mycophenolic acid: decreased resistance to fluconazole: decreased resistance to cycloheximide: decreased resistance to hydroxyurea: increased sporulation efficiency: increased viable
unspecified	resistance to Calcofluor White: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	76 total interaction(s) for 51 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Biochemical Activity: 2 Co-purification: 1 Two-hybrid: 11
Genetic Interactions	Negative Genetic: 21 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 9 Synthetic Growth Defect: 18 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:392279 to 390240 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2040 392279..390240 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001508