PAM1/YDR251W Summary Help

Standard Name PAM1 1
Systematic Name YDR251W
Feature Type ORF, Verified
Description Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype; PAM1 has a paralog, SVL3, that arose from the whole genome duplication (2, 3, 4)
Name Description Pp2A Multicopy suppressor 2
Chromosomal Location
ChrIV:960614 to 963106 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PAM1 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 1 genes
Resources
Large-scale survey
null
overexpression
Resources
40 total interaction(s) for 35 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 1
  • Biochemical Activity: 4
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Dosage Rescue: 3
  • Negative Genetic: 7
  • Positive Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 830
Molecular Weight (Da) 92,871
Isoelectric Point (pI) 8.78
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:960614 to 963106 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2493 960614..963106 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002659
References cited on this page View Complete Literature Guide for PAM1
1) Ronne, H.  (1992) Personal Communication, Mortimer Map Edition 11
2) Hu GZ and Ronne H  (1994) Overexpression of yeast PAM1 gene permits survival without protein phosphatase 2A and induces a filamentous phenotype. J Biol Chem 269(5):3429-35
3) Minarikova L, et al.  (2001) Differentiated gene expression in cells within yeast colonies. Exp Cell Res 271(2):296-304
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61