PAC11/YDR488C Summary

PAC11 BASIC INFORMATION

Standard Name	PAC11
Systematic Name	YDR488C
Feature Type	ORF, Verified
Description	Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8 (1, 2)
Name Description	Perishes in the Absence of CIN8 1

GO Annotations	All PAC11 GO evidence and references
	View Computational GO annotations for PAC11
Molecular Function
Manually curated	microtubule motor activity (ISS) contributes_to plus-end-directed microtubule motor activity (IMP)
Biological Process
Manually curated	microtubule-based process (IGI) nuclear migration along microtubule (IMP)
Cellular Component
Manually curated	cytoplasmic dynein complex (TAS) cytoplasmic microtubule (IDA, IPI)

Mutant Phenotype	All PAC11 Phenotype details and references
Classical genetics
null	nuclear position: abnormal
Large-scale survey
null	competitive fitness: decreased resistance to ethanol: decreased viable

Interactions	PAC11 All interactions details and references
	View additional details at BioGRID
	246 total interaction(s) for 149 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Two-hybrid: 5
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 182 Phenotypic Enhancement: 1 Positive Genetic: 12 Synthetic Growth Defect: 3 Synthetic Lethality: 35

Sequence Information

ChrIV:1430782 to 1429181 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1602	1430782..1429181	2008-06-05	1996-07-31

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002896

PAC11 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PAC11

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PAC11]

1)	Winsor B and Schiebel E (1997) Review: an overview of the Saccharomyces cerevisiae microtubule and microfilament cytoskeleton. Yeast 13(5):399-434
2)	Farkasovsky M and Kuntzel H (2001) Cortical Num1p interacts with the dynein intermediate chain Pac11p and cytoplasmic microtubules in budding yeast. J Cell Biol 152(2):251-62

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