OYE2/YHR179W Summary Help

Standard Name OYE2 1
Systematic Name YHR179W
Feature Type ORF, Verified
Description Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5, 6, 7)
Name Description Old Yellow Enzyme 2
Gene Product Alias Old Yellow Enzyme
Chromosomal Location
ChrVIII:462502 to 463704 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All OYE2 GO evidence and references
  View Computational GO annotations for OYE2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 21 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
89 total interaction(s) for 73 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 30
  • Affinity Capture-RNA: 4
  • Co-fractionation: 1
  • PCA: 1
  • Protein-peptide: 2
  • Reconstituted Complex: 1

Genetic Interactions
  • Negative Genetic: 45
  • Phenotypic Suppression: 1
  • Positive Genetic: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 400
Molecular Weight (Da) 45,010
Isoelectric Point (pI) 6.54
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:462502 to 463704 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1203 462502..463704 2005-11-07 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001222
References cited on this page View Complete Literature Guide for OYE2
1) Stott K, et al.  (1993) Old Yellow Enzyme. The discovery of multiple isozymes and a family of related proteins. J Biol Chem 268(9):6097-106
2) Niino YS, et al.  (1995) A new old yellow enzyme of Saccharomyces cerevisiae. J Biol Chem 270(5):1983-91
3) Brown BJ, et al.  (2002) The role of glutamine 114 in old yellow enzyme. J Biol Chem 277(3):2138-45
4) Trotter EW, et al.  (2006) Old yellow enzymes protect against acrolein toxicity in the yeast Saccharomyces cerevisiae. Appl Environ Microbiol 72(7):4885-92
5) Odat O, et al.  (2007) Old Yellow Enzymes, Highly Homologous FMN Oxidoreductases with Modulating Roles in Oxidative Stress and Programmed Cell Death in Yeast. J Biol Chem 282(49):36010-23
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Steyer D, et al.  (2013) Genetic analysis of geraniol metabolism during fermentation. Food Microbiol 33(2):228-34