Standard Name	OSH3
Systematic Name	YHR073W
Feature Type	ORF, Verified
Description	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability (1)
Name Description	OxySterol binding protein Homolog 1

Chromosomal Location	ChrVIII:242582 to 245572 | ORF Map | GBrowse

	View Computational GO annotations for OSH3
Molecular Function
Manually curated	1-phosphatidylinositol binding (ISS) lipid binding (IDA) oxysterol binding (ISS) sterol transporter activity (IDA)
Biological Process
Manually curated	endocytosis (IGI) exocytosis (IGI) invasive growth in response to glucose limitation (IGI) karyogamy involved in conjugation with cellular fusion (IGI) maintenance of cell polarity (IGI) positive regulation of phosphatase activity (IDA) pseudohyphal growth (IMP) sterol transport (IDA, IGI, IMP)
Cellular Component
Manually curated	cortical endoplasmic reticulum (IDA) cytoplasm (IDA)

Classical genetics
null	cold sensitivity: decreased pseudohyphal growth: increased resistance to aureobasidin A: normal resistance to benomyl: increased resistance to ISP-1: increased viable
overexpression	pseudohyphal growth: increased resistance to SP-1: decreased
Large-scale survey
null	competitive fitness: increased resistance to sirolimus: decreased resistance to neothyonidioside: decreased resistance to wortmannin: normal stress resistance: increased toxin resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	50 total interaction(s) for 47 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Biochemical Activity: 7 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 14 Phenotypic Enhancement: 3 Positive Genetic: 6 Synthetic Growth Defect: 7 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:242582 to 245572 | ORF Map | GBrowse
	This feature contains embedded feature(s): YHR073C-B | YHR073W-A
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2991 242582..245572 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001115